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CONTRAVE can cause serious side effects of suicidal thoughts or actions.

One of the ingredients in CONTRAVE is bupropion HCl. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.

Stop taking CONTRAVE and call a healthcare provider right away if you, or your family member, have any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling very agitated or restless; panic attacks; trouble sleeping (insomnia); irritability; acting aggressive, being angry or violent; acting on dangerous impulses; an extreme increase in activity and talking (mania); other unusual changes in behavior or mood.

While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings and maintain communication with your healthcare provider. CONTRAVE has not been studied in and is not approved for use in children under the age of 18.

Do not take CONTRAVE if you:

Have uncontrolled high blood pressure
Have or have had seizures
Use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, and APLENZIN
Have or have had an eating disorder called anorexia or bulimia
Are dependent on opioid pain medicines or use medicines to help stop taking opioids such as methadone or buprenorphine, or are in opiate withdrawal
Drink a lot of alcohol and abruptly stop drinking, as this may increase your chance of having a seizure; or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti-seizure medicines and you stop using them all of a sudden
Have taken medicines called monoamine oxidase inhibitors (MAOIs), including linezolid, within the last 14 days
Are allergic to naltrexone HCl or bupropion HCl or any of the ingredients in CONTRAVE
Are pregnant or planning to become pregnant. Tell your healthcare provider right away if you become pregnant while taking CONTRAVE

Tell your healthcare provider about all of your medical conditions, especially: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of your brain or spine; low blood sugar or low levels of sodium in your blood; liver or kidney problems; high blood pressure; heart problems or stroke; eating disorder. Also tell your doctor if you drink a lot of alcohol and plan to suddenly stop; abuse prescription medicines or street drugs; are over the age of 65; have any other medical conditions; or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them.

Swallow CONTRAVE tablets whole. Do not cut, chew, or crush CONTRAVE tablets. Tell your healthcare provider if you cannot swallow CONTRAVE tablets whole. Do not take CONTRAVE with high-fat meals. It may increase your risk of seizures. Take CONTRAVE exactly as prescribed.

Possible serious side effects of CONTRAVE:

If you have a seizure, stop taking CONTRAVE, tell your healthcare provider right away, and do not take CONTRAVE again
If you take opioid medicines, there may be a risk of opioid overdose. You should get emergency medical help right away if you have trouble breathing; become drowsy with slowed breathing; have slow, shallow breathing; or feel faint, dizzy, or confused
Sudden opioid withdrawal can be severe and may require hospitalization
Stop taking CONTRAVE and get medical help immediately if you have any of the following signs and symptoms of severe allergic reactions: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing
Increases in blood pressure or heart rate may occur
CONTRAVE can cause liver damage or hepatitis. Stop taking CONTRAVE if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness
Manic episodes can occur. CONTRAVE can cause some people who were manic or depressed in the past to become manic or depressed again
CONTRAVE can cause visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your doctor to find out if you are at risk and to get treatment to prevent it
Increased risk of low blood sugar (hypoglycemia) in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start and while taking CONTRAVE

The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea.

Tell your healthcare provider about any side effect that bothers you or does not go away. These are not all the possible side effects of CONTRAVE.

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Contrave had a 2 to 1 ratio of success to side effects related discontinuation (1 out of 2 patients quit)

Belviq had a 10.6 to 1 odds of losing weight versus quitting due to adverse side effects. (1 out of 10.6 patients quit)

See for reviews and and for full prescribing and safety info.


Patient wrote about Contrave:

"I was on Contrave...I had the worst side effects!! Pounding headaches, tired all the time, crabby, constipation...OMG the list goes on!!!"

Patient wrote about Contrave:

"Omg for Contrave I had migraines which I do suffer from them anyways. But these were worse, I felt extremely tired all of the time. Which sucked so much and I also had nausea and it did not at all make me not want to eat certain things the only thing I gave up was coffee. The thought of it made me sick.. Like really coffee even my dr was like what? Coffee is supposed to help ur metabolism so it was crazy.. Right now with the Phentermine and Belviq I can say that I have had no side effects."

Patient wrote about Contrave:

"I informed him of this upper left side pain I've been having for a few months that urgent care doctors said was a pulled muscle. My doctor examined my belly and said I'm severely severely constipated due to my contrave most likely and to drink one dose of miralax and in a week up it to two a day if I see no results. I took the dose around 7pm. I've been up for about 4 or 5 hours now without having actually been to sleep. Not only am I in THE WORST pain I've ever been in, I've thrown up 4 times, I'm sweating, shaky, dizzy and extremely paranoid anxiety attack like. Good thing I have a math final at 10am right???? I looked online to see if others have experienced the same problems as me and almost every single review people either had to go to the ER or felt like they were dying"

Patient wrote about Contrave:

"My niece gave up on Contrave. Her hands shook so bad and it continued for 5 days after stopping. "

Patient wrote about Contrave:

“Everything was going great till last week; every time I eat now I get the worst stomach pains EVER & have diarrhea and the sweats. I thought I was sick at first but now I think it's the Contrave.”

Patient wrote about Contrave:

"Today I went to the ER with the worst stomach pain ever. It seems like my stomach hurts when I eat. I also get nauseous, sweaty, and sometimes don't have bowel movements for days. The cramps are the worst. “

Patient wrote about Contrave:

"My mental well being was not good. Not good at all. Very disappointing. "

Patient wrote about Contrave:

”I have lost almost nothing for nearly 2 months now. I have been on the full dose since Christmas day. My body and mind feel exactly like they did before starting Contrave. I crave everything. Coffee is delicious again. Dry mouth and constipation are gone. I have gained 5 lbs since last Friday!!”

Patient wrote about Contrave:

“As time progressed, I was getting into a dark mental place. But for me, certain meds do that to me. I stopped it last week and the first couple days were a little rough but I am starting to feel normal.”

Patient wrote about Contrave:

“I wasn't seeing the weightloss very much with Contrave and had headaches (more than normal).”

A Top Cardiologist Says Maker Of Contrave Misled Patients And Investors

The supposed benefit almost disappeared as time passed. As the number of heart attacks, strokes, and cardiovascular deaths increased from 94 to 192, the 41% difference between those getting Contrave and those getting placebo shrank to just 12% and was no longer statistically significant. More evidence it may be meaningless: patients given Contrave were more likely to have chest pain and more likely to die from causes other than heart disease. Many patients who supposedly had a benefit had actually stopped taking the drug.

“Patients were misled, investors were misled,” says Nissen. “It is so critically important that investors and other people understand why early data in a trial are unreliable or unstable.”

Contrave Study Crashes And Burns In The Wake Of Leaked Results

The Cleveland Clinic press release includes important additional information about the trial from the 50% interim analysis. Most importantly, the new results failed to confirm the earlier finding of cardiovascular benefit. The new analysis contains a total of 192 endpoint major adverse cardiovascular events: 102 in the placebo group compared with 90 in the Contrave group (HR=0.88, CI 0.66 – 1.17). This result reflects a shift in the outcomes: the early benefit in the first quarter of the trial was reversed in the second quarter, in which there were 43 events in the placebo group and 55 events in the Contrave group.

With some bitterness Nissen notes that Orexigen was “perfectly willing to allow” the positive data from the 25% analysis to be made public but not the data from the 50% analysis. After 6 weeks of negotiations the companies announced the termination of the trial but did not include the data from the 50% analysis. ”We felt it was important to get this information out to the public,” said Nissen. The trial leaders therefore issued their own press release.